直至最近,噻嗪类利尿剂仍是治疗轻至中度原发性高血压所选择的药物,但多数患者单用噻嗪类药物治疗是无效的,而必须加用第二种药物,醋丁酰心安是一最新的β—阻滞剂,其抗高血压的作用已经临床证实。作者应用严格限制的双盲交叉法对单用利尿药不能控制的高血压病人加用醋丁酰心安以确定其疗效,并观察了两药对血浆肾素活性及血浆醛固酮的影响。 Until recently, thiazide diuretics were still the drug of choice for the treatment of mild-to-moderate essential hypertension, but most patients were ineffective with thiazide alone and had to add a second drug, Aloxacin is a new beta-blocker whose antihypertensive effect has been clinically confirmed. The authors applied the strictly limited double-blind crossover method to evaluate the curative effect of patients with hypertensive patients who could not be controlled by diuretics alone, and observed the effect of the two drugs on plasma renin activity and plasma aldosterone.