GH4169 alloy has been widely used in fields such as aviation, aerospace, and petrochemical, because of its excellent combination of mechanical and processing properties. These properties include good high-temperature strength, excellent creep and fatigue resistance, and good processing and welding performance. The requirement for high performance, high reliability, and long service life of modern engines has led to the incentive to develop GH4169 alloys with improved performance, such as increased temperature-bearing capacity, improved creep endurance, and better fatigue resistance. Advances during the past thirty years in basic research and industrial technology related to GH4169 alloy were systematically summarized, including advances in alloy modification, melting process optimization, and hot deformation technology. GH4169 alloy has been widely used in fields such as aviation, aerospace, and petrochemical, because of its excellent combination of mechanical and processing properties. These properties include good high-temperature strength, excellent creep and fatigue resistance, and good processing and welding performance. The requirement for high performance, high reliability, and long service life of modern engines has led to the incentive to develop GH4169 alloys with improved performance, such as increased temperature-bearing capacity, improved creep endurance, and better fatigue resistance. Advances during the past thirty years in basic research and industrial technology related to GH4169 alloy were systematically summarized, including advances in alloy modification, melting process optimization, and hot deformation technology.