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目的 :探讨幽门螺杆菌 (Helicobaterpylori,Hp)所致胃肠道不同部位的病变与其机体免疫反应的相互关系。方法 :采用免疫印迹法和间接ELISA法分别检测患者血清中Hp -CagAIgG抗体和Hp -IgE抗体含量。结果 :在 350例Hp感染患者血清中Hp -CagA抗体阳性率为 80 .2 8%明显高于Hp -IgE58.57% ,P <0 .0 1 ;不同病变部位的阳性率 ,Hp -CagAIgG含量 :慢性活动性胃炎 (ACG)和十二指肠球部溃疡 (DU)明显高于慢性非活动性胃炎 (NACG)、胃溃疡 (GU)、胃癌 (GCa)及溃疡性结肠炎 (UC) ,P <0 .0 1 ;Hp -IgE含量 :ACG明显高于其它被测的任何一组。结论 :在Hp感染过程中 ,Hp -CagAIgG抗体和IgE抗体参与了炎症反应 ,在十二指肠球部溃疡和慢性活动性胃炎的过程中起了极其重要作用
Objective: To investigate the relationship between the lesions of different parts of the gastrointestinal tract caused by Helicobaterpylori (Hp) and its immune response. Methods: The serum levels of Hp-CagAIgG and Hp-IgE were detected by Western blotting and indirect ELISA respectively. Results: The positive rate of Hp-CagA antibody in serum of 350 patients with Hp infection was 80.28%, which was significantly higher than that of Hp -IgE58.57%, P <0.01. The positive rates of Hp-CagAIgG Chronic active gastritis (ACG) and duodenal ulcer (DU) were significantly higher than those of chronic non-active gastritis (NACG), gastric ulcer (GU), gastric cancer (GCa) and ulcerative colitis (UC) P <0. 01; Hp -IgE content: ACG was significantly higher than any other test of any group. CONCLUSIONS: Hp-CagAIgG and IgE antibodies are involved in the inflammatory response during Hp infection and play an extremely important role in the pathogenesis of duodenal ulcer and chronic active gastritis