Posener 报告癌患者之15%～20%有严重的神经系统合并症,认为这些合并症是使癌患者残废和死亡的重要原因之一。1958年Brain 首先应用癌性神经肌肉病变(carcino-matous neuromyopathy,简称CN)这一名称。其意义是指:恶性肿瘤患者所出现的非癌肿转移所致的、目前尚不易解释的中枢神经、末梢神经和肌肉的病变。恶性肿瘤患者合并CN 之 Posener reports that 15% to 20% of cancer patients have severe neurological complications and that these complications are one of the important causes of disability and death of cancer patients. 1958 Brain first application of cancerous neuromuscular disease (carcinomatous neuromyopathy, referred to as CN) this name. Its meaning is: malignant tumor patients appear non-cancerous metastasis, is not yet easy to explain the central nervous, peripheral nerve and muscle lesions. Malignant tumor patients with CN