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目的观察无干眼症状的儿童过敏性结膜炎患者的泪膜稳定性。设计回顾性病例系列。研究对象无干眼症状的儿童季节性过敏性结膜炎患者30例(60眼)。无干眼症状的屈光不正患儿20例(40眼)为正常对照组。方法受试者进行病史询问以及外眼、眼前节及干眼相关检查,包括泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)、角膜荧光素染色(FL)。荧光素染色评分0~12分,无染色为0分。主要指标BUT、SIt和FL评分。结果观察组与对照组BUT分别为(7.35±2.46)s、(11.95±2.183)s(t=9.569,P=0.000);SIt分别为(18.28±5.123)mm、(16.50±5.149)mm(t=1.702,P=0.092);FL评分不为0者分别为13例(20眼)、6例(6眼)(χ2=4.193,P=0.041)。观察组中FL评分、BUT与病史长短无显著相关性。结论无干眼症状的儿童季节性过敏性结膜炎患者也可能存在泪膜稳定性下降和角膜上皮完整性受损的改变。
Objective To observe the tear film stability in children with allergic conjunctivitis without dry eye symptoms. Design retrospective case series. Thirty patients (60 eyes) with seasonal allergic conjunctivitis were included in the study. No dry eye symptoms of refractive errors in 20 children (40 eyes) as the normal control group. Methods The subjects were asked about their medical history and examination of the external eye, anterior segment and dry eye, including the time of rupture of the tear (BUT), the basal tear secretion test (SIt) and the corneal fluorescein staining (FL). Fluorescein staining score 0 to 12 points, no staining 0 points. The main indicators of BUT, SIt and FL score. Results The BUT of observation group and control group were (7.35 ± 2.46) s, (11.95 ± 2.183) s (t = 9.569, P = 0.000) and SIt were (18.28 ± 5.123) mm and = 1.702, P = 0.092). The patients with FL score other than 0 were 13 (20 eyes) and 6 eyes (6 eyes) (χ2 = 4.193, P = 0.041). FL score in the observation group, BUT and the length of history no significant correlation. Conclusions Patients with seasonal allergic conjunctivitis without dry eye symptoms may also have altered tear film stability and impaired corneal epithelial integrity.