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本文回顾了应用麻疹活疫苗的历史。以用于9月龄婴儿的标准麻疹疫苗是安全有效的。为克服4～6月龄婴儿体内存在的母体抗体的干扰,世界卫生组织(WHO)曾于1989年建议,在麻疹是主要导致9月龄以内婴儿亡原因之一的地区,可以常规接种高滴度疫苗。然而,3年来的实践发现,接受高滴度疫苗儿童的死亡率高于标准滴度疫苗接种者,并有性别差异。1991年WHO规定应对接种高滴度疫苗的人群进行长期随访,1992年规定停止使用高滴度麻疹疫苗。
This article reviews the history of live measles vaccine use. The standard measles vaccine for 9-month-old infants is safe and effective. In order to overcome the interference of maternal antibodies present in babies aged 4 to 6 months, the World Health Organization (WHO) recommended in 1989 that in areas where measles is one of the major causes of infant death within 9 months, high drop Degree vaccine. However, three years of practice have found that children receiving high titer vaccines have higher mortality rates than standard titer vaccines and have gender differences. In 1991, the WHO stipulated that long-term follow-up should be carried out among those who were vaccinated with high-titer vaccines. In 1992, they stopped using high-titer measles vaccines.