一、引言通常认为甲状腺机能和生长是受垂体前叶控制的,通过它们所分泌的两种激素相互消长的反馈作用达到平衡。这概念主要是基于整体试验的组织学观察结果,要深入阐明甲状腺的调制机制,还必须进行体内激素活性变化的直接测定。但由于激素测定方法的灵敏度和可靠性的限制,而且体液内激素含量常甚为微弱,还可能有干扰因素或毒性物质 I. INTRODUCTION It is generally accepted that thyroid function and growth are controlled by the anterior pituitary and are balanced by the feedback of the mutual excretion of the two hormones secreted by them. The concept is based primarily on the histological observations of the overall test. To further elucidate the regulatory mechanism of the thyroid gland, a direct determination of changes in the hormone activity in the body must also be performed. However, due to the limitations of the sensitivity and reliability of the hormone assay and the often low levels of hormones in the body fluids, interferences or toxic substances may also be present