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苯妥英钠（ＤＰＨ＿Ｎａ）常用于预防与治疗癫痫大发作、精神运动性发作及心律失常等。但其具有（１）非线性药动学和饱和代谢;（２）有效血药浓度范围窄;（３）个体间差异大３个特征,使得ＤＰＨ＿Ｎａ给药方案设计较为困难。有关ＤＰＨ＿Ｎａ的个体化给药方案设计,已有较多文
Phenytoin sodium (DPH_Na) commonly used in the prevention and treatment of epileptic seizures, psychomotor seizures and arrhythmias. (1) nonlinear pharmacokinetics and saturation metabolism; (2) narrow range of effective plasma concentration; (3) three characteristics of large differences between individuals, making the design of DPH_Na dosing scheme more difficult. There have been more articles on the design of individual dosing regimens for DPH_Na