本文对４８名铅作业男工血铅（ＰｂＢ）、精铅（ＰｂＳ）、血清黄体生成素（ＬＨ）、血清卵泡刺激素（ＦＳＨ）、血浆睾丸酮水平及其相互关系进行了研究，结果发现血铅、精铅明显高于对照组（Ｐ＜０．０５）；血清ＬＨ明显高于对照组（Ｐ＜０．０５）；ＦＳＨ、血浆睾丸酮含量明显低于对照组（Ｐ＜０．０５）；血铅高浓度组血清ＬＨ明显高于血铅低浓度组（Ｐ＜０．０１）；而ＦＳＨ、Ｔ明显降低（Ｐ＜０．０５）；精铅高浓度组ＬＨ明显高于精铅低浓度组（Ｐ＜０．０１），而Ｔ明显低于精铅低浓度组（Ｐ＜０．０５）；提示铅可损伤下丘脑－垂体－睾丸轴的正常生理功能；铅影响男性某些性激素的分泌功能可能是铅中毒的重要机制之一。 In this paper, 48 lead male lead (PbB), lead (PbS), serum luteinizing hormone (LH), serum follicle stimulating hormone (FSH), plasma testosterone levels and their correlation were studied and found that blood (P <0.05); serum LH was significantly higher than that of the control group (P <0.05); FSH and plasma testosterone contents were significantly lower than those of the control group (P <0.05); The level of serum LH was significantly higher in high blood lead group than in low blood lead group (P <0.01), but FSH and T were significantly lower (P <0.05); LH in high blood lead group was significantly higher than that in low blood lead (P <0.01), while T was significantly lower than that of the low concentration of lead (P <0.05). It suggested that lead could damage the normal physiological function of the hypothalamic-pituitary-testicular axis. Lead affected some sex hormones Secretion may be one of the important mechanisms of lead poisoning.