骨髓增生异常综合征(MDS)是一组变异性较大的克隆性造血系统疾病,多死于感染和出血等并发症或转化为急性白血病,病程长短不一.随着造血祖细胞体外培养体系的发展和方法上的改进,为探讨包括MDS在内的各种造血异常性疾病的发病机理提供了一种十分有用的手段.MDS造血祖细胞体外培养研究概况1.粒单祖细胞的异常生长:对MDS造血细胞体外培养研究最多的是粒单祖细胞(CFU-GM),其结果在总体上是相似的.大多数MDS患者,CFU-GM的生长与正常造血细胞相比有明显的异常,只是各家报道这些异常出现的频率和严重程度不同而已.主要包括CFU-GM形成率减少或缺乏,集落与集簇的比值变 Myelodysplastic syndrome (MDS) is a group of more hereditary clonal hematopoietic system diseases, more often died of complications such as infection and bleeding or into acute leukemia, the duration of the disease varies with the system of hematopoietic progenitor cells in vitro Development and methodological improvement, which provide a very useful method for exploring the pathogenesis of various hematopoietic disorders including MDS.MDS hematopoietic progenitor cells in vitro 1. Abnormal growth of granulocyte-progenitor cells : The most commonly studied MDS hematopoietic cells cultured in vitro are granulocyte-progenitor cells (CFU-GM), and the results are generally similar. In most patients with MDS, CFU-GM is significantly abnormal compared to normal hematopoietic cells , But only reported the frequency and severity of these abnormalities are different, including the reduction or lack of CFU-GM formation rate, the ratio of colony to cluster