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The electrophysiological and pharmacological properties of taurine（Tau）－activated Cl－currents（nau） were investigated inthe dissociated rat sacral dorsal commissural nucleus（SDCN） neurons using the nystatin perforated patch recordingconfigura－tion under voltage－clamp conditions． The reversal potential of ITau was close to the Cl－equilibrium potential．The ITau was notaffected by a preceding GABA response but cross-desensitized by a preceding glycine (Gly) response．Strychnine（STR）, picro－toxin（PIC），bicuculline（BIC） and Zn2＋suppressed the ITau in a concentration－dependent manner．The pharmacology of theITau and Gly－induced response（IGly） was similar， though Zn2＋inhibition on ITau differed from that on IGly in being muchslower in recovery．Serotonin potentiated the ITau via protein kinase C．The results indicate that both Tau and Gly act on astrychnine－sensitive site to open the same CI－channels in the SDCN neurons， and suggest that Tau may act as a functional neu－rotransmitter in the mammalian SDCN．Copyright 1998 Elsevier Science B．V．
The electrophysiological and pharmacological properties of taurine (Tau) -activated Cl-currents (nau) were investigated inthe dissociated rat sacral dorsal commissural nucleus (SDCN) neurons using the nystatin perforated patch recording configura- tion under voltage-clamp conditions. The reversal potential of ITau was close to the Cl-equilibrium potential. The ITau was not affected by a preceding GABA response but cross-desensitized by a preceding glycine (Gly) response. Strychnine (STR), picro-toxin (PIC), bicuculline (BIC) and Zn2 + suppressed the ITau in a concentration-dependent manner. The pharmacology of the Tau and Gly-induced response (IGly) was similar, though Zn2 + inhibition on ITau differed from that on IGly in being much slowdown in recovery. Serotonin potentiated the ITau via protein kinase C. The results indicate that both Tau and Gly act on astrychnine-sensitive site to open the same CI-channels in the SDCN neurons, and suggest that Tau may act as a functional neu-rotransmitter in the mammalian SDCN. Copyright 1998 Elsevier Science B. V.