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目的:观察夜间营养支持对乙型肝炎肝硬化患者营养状态和肝功能的影响。方法:选择贵州医科大学附属医院2018年4－8月治疗的乙型肝炎肝硬化患者60例为研究对象，采用随机数字表法分为干预组30例、对照组30例。两组均给予内科基础治疗，干预组采用基础治疗加用复合功能性营养素30 g口服，每晚1次，干预12周。每4周观察两组患者的肝功能及营养状态变化，同时记录并发症发生情况。结果:干预前，两组血清白蛋白(Alb)、前白蛋白(PA)、总胆红素(TBlL)及体质指量数(BMI)、肱三头肌皮褶厚度(TSF)、握力差异均无统计学意义(均n P>0.05)。干预12周末，干预组ALb、PA、TBIL、BMI、TSF、握力分别为(32.61±1.78)g/L、(116.65±11.92)g/L、(36.6±5.86)μmol/L、(22.23±2.92)kg/mn 2、(17.34±1.31)mm、(23.36±2.44)kg，均较干预前改善，对照组分别为(30.38±1.58)g/L、(101.22±7.76)g/L、(47.75±4.83)μmol/L、(21.07±2.11)kg/mn 2、(16.07±1.40)mm、(20.01±2.70)kg，两组差异均有统计学意义(n t＝4.946、5.105、5.881、2.407、2.272、3.805，均n P0.05). After 12 weeks of intervention, the albumin [(32.61±1.78) g/L], pre-albumin [(116.65±11.92) g/L], total bilirubin [(36.6±5.86)μmol/L], body mass index [(22.23±2.92) kg/mn 2], skinfold [(17.34±1.31) mm], the grip strength [(23.36±2.44)kg] in the intervention group were superior to the control group[(30.38±1.58)g/L, (101.22±7.76)g/L, (47.75±4.83)μmol/L, (21.07±2.11)kg/mn 2, (16.07±1.40)mm, (20.01±2.70)kg], the differences were statistically significant between the two groups(n t=4.946, 5.105, 5.881, 2.407, 2.272, 3.805, all n P<0.05). The incidence of the complications in the intervention group was 10%(3/30), which in the control group was 33%(10/30), the difference was statistically significant between the two groups(χn 2=4.381, n P=0.033).n Conclusion:Providing nutritional support at night can improve the nutritional status of patients with hepatitis B cirrhosis, promote the repair of liver function, and reduce the incidence of complications.