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目的探讨血清25-(OH)D3及钙(Ca2+)水平与胃癌的关系。方法选取郑州大学第一附属医院经病理确诊为慢性浅表性胃炎(对照组)患者63例,胃癌(病例组)患者118例。采用酶联免疫吸附法(ELISA)测定入选对象血清25-(OH)D3水平,离子选择性电极(ISE)电位法测定入选对象血清Ca2+水平。结果病例组外周血25-(OH)D3水平显著低于对照组(t=15.07,P=0.000),而其血清Ca水平与对照组比较,差异无统计学意义(t=1.109,P=0.269),病例组内血清25-(OH)D3水平与Ca2+之间呈正相关(r=0.706,P=0.000)。外周血25-(OH)D3水平在不同细胞分化程度的胃癌组间差异有统计学意义(F=3.356,P=0.038)。胃癌经手术治疗后,术后外周血25-(OH)D3水平高于术前,差异有统计学意义(t=-8.017,P=0.000)。但胃癌淋巴结转移与无淋巴结转移组间血清25-(OH)D3水平无统计学意义(t=0.061,P=0.952)。结论血清25-(OH)D3水平可能与胃癌的发生、发展相关,手术治疗后其水平明显升高,可用于监测胃癌患者病情变化、预测预后。
Objective To investigate the relationship between serum 25- (OH) D3 and calcium (Ca2 +) levels and gastric cancer. Methods Sixty-three patients with pathological diagnosis of chronic superficial gastritis (control group) and 118 patients with gastric cancer (case group) were selected from the First Affiliated Hospital of Zhengzhou University. Serum 25- (OH) D3 levels were measured by enzyme-linked immunosorbent assay (ELISA), serum Ca2 + levels were measured by ISE potentiometry. Results The level of 25- (OH) D3 in the peripheral blood of the patients was significantly lower than that of the control group (t = 15.07, P = 0.000). There was no significant difference in serum Ca levels between the two groups (t = 1.109, P = 0.269 ). There was a positive correlation between serum 25- (OH) D3 level and Ca2 + in the case group (r = 0.706, P = 0.000). The difference of 25- (OH) D3 levels in peripheral blood between gastric cancer patients with different degrees of cell differentiation was statistically significant (F = 3.356, P = 0.038). After surgery, the level of 25- (OH) D3 in peripheral blood of patients with gastric cancer was significantly higher than that before operation (t = -8.017, P = 0.000). However, serum 25- (OH) D3 levels between gastric cancer with lymph node metastasis and non-lymph node metastasis were not statistically significant (t = 0.061, P = 0.952). Conclusions The level of serum 25- (OH) D3 may be related to the occurrence and development of gastric cancer. The level of serum 25- (OH) D3 may be significantly increased after operation. It may be used to monitor the changes of gastric cancer patients and predict the prognosis.