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目的 探讨 5′- DFU R(氟铁龙 )化疗方案在胃和结、直肠癌根治术后老年患者中的应用 ,寻找更符合这类患者的术后化疗方法。方法 选择了自 1994年 1月～ 1998年12月间 5 0例胃和结、直肠癌根治术后应用 5′- DFU R化疗的老年患者与 5 0例应用 5 - FU联合化疗的老年患者 ,对两组术后化疗方案进行回顾性的对比。比较项目包括 :患者对化疗药物的毒副反应 ;肿瘤的转移和复发 ;化疗后并发症 ;生存率 ;生活质量测评 ;平均住院日及费用等。结果 患者对化疗药物的毒副反应 ;化疗并发症和生活质量测评等项目 ,5′-DFU R组优于 5 - FU联合化疗组。而肿瘤的转移、复发和生存率两组比较无明显差别 ;平均住院日 5′- DFU R组低于 5 -FU联合化疗组 ;而平均医疗费用 5′- DFUR组并不高于 5 -FU联合化疗组。结论 5′- DFU R在治疗胃和结、直肠癌根治术后的老年患者中 ,综合效果优于 5 - FU联合化疗
Objective To investigate the application of chemotherapy regimen of 5’-DFU R in elderly patients with gastric and colorectal cancer after radical resection and find out more suitable postoperative chemotherapy for these patients. Methods From January 1994 to December 1998, 50 elderly patients with 5’- DFU R chemotherapy after radical resection of stomach and colorectal carcinoma and 50 elderly patients treated with 5 - FU combined with chemotherapy were enrolled. The two groups of postoperative chemotherapy regimen were retrospectively compared. Comparison items include: patients with chemotherapy drugs side effects; tumor metastasis and recurrence; postoperative chemotherapy complications; survival rate; quality of life evaluation; average length of stay and costs. Results The patients had adverse reactions to chemotherapeutic drugs, chemotherapy complications and quality of life evaluation. The 5-DFU group was better than the 5-FU combined with chemotherapy group. However, there was no significant difference between the two groups in metastasis, recurrence and survival rate of the tumor. The mean length of stay in 5’- DFU R group was lower than that of 5 -FU combined chemotherapy group, while the average medical cost 5’- DFUR group was not higher than 5 -FU Combination chemotherapy group. CONCLUSIONS: 5-DFU R is superior to 5-FU combined with chemotherapy in the treatment of elderly patients with gastric and colorectal cancer after radical resection