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目的研究生长激素受体(GHR)在结直肠癌中的表达情况,了解生长激素(GH)在结直肠癌发生、发展中的作用。方法应用免疫组织化学法(IHC)测定100例结直肠癌标本及其附近正常黏膜中GHR的表达情况,同时测定Ki-67表达。分析结直肠癌组织与正常黏膜GHR的表达及其与临床病理因素和肿瘤的关系。结果结直肠癌中GHR表达(81%)明显高于正常黏膜(68%),GHR的表达与肿瘤分化程度、病理分期、肿瘤大小相关(P=0.047、P=0.003和P=0.017),并与肿瘤增殖相关(P<0.001)。结论GHR在结直肠癌组织中有较高的阳性表达,提示GHR的表达是结直肠癌发生、发展过程中的重要事件,结直肠癌患者应用GH应慎重。
Objective To study the expression of growth hormone receptor (GHR) in colorectal cancer and to understand the role of growth hormone (GH) in the occurrence and development of colorectal cancer. Methods Immunohistochemistry (IHC) was used to determine the expression of GHR in 100 specimens of colorectal cancer and its adjacent normal mucosa, and to determine the expression of Ki-67. To analyze the expression of GHR in colorectal cancer tissues and normal mucosa and its relationship with clinicopathological factors and tumor. Results The expression of GHR in colorectal carcinoma was significantly higher than that in normal mucosa (81%). The expression of GHR was correlated with tumor differentiation, pathological stage and tumor size (P = 0.047, P = 0.003 and P = 0.017) Associated with tumor proliferation (P <0.001). Conclusions GHR is highly expressed in colorectal cancer tissues, suggesting that the expression of GHR is an important event in the development and progression of colorectal cancer. GH should be used with caution in patients with colorectal cancer.