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目的:观察番茄红素对小鼠前胃组织癌变过程的影响及其作用机制。方法:昆明小鼠随机分成4组,番茄红素组分别饲喂高、中、低不同剂量的番茄红素饲料,模型组饲喂正常饲料,2周后灌喂含苯并(a)芘的色拉油,24周后处死全部动物,观察小鼠前胃癌形成情况,测定血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT),谷胱甘肽过氧化物酶(GSH-Px)活性、总抗氧化活力(T-AOC)、丙二醛(MDA)和还原型谷胱甘肽(GSH)含量。结果:与模型组相比,番茄红素高剂量组成瘤率和瘤直径显著减小,MDA含量降低,CAT、GSH-Px活力明显升高,高、中剂量组SOD、T-AOC活性升高。结论:番茄红素具有抑制肿瘤生长的作用,其作用机制可能与提高抗氧化酶活力,降低脂质过氧化产物有关。
Objective: To observe the effect of lycopene on the carcinogenesis of mouse anterior gastric tissue and its mechanism. Methods: Kunming mice were randomly divided into 4 groups. Lycopene groups were fed with high, medium and low doses of lycopene respectively. The model group was fed with normal diet and fed with pyrene containing benzo (a) All the animals were killed after 24 weeks and the formation of gastric precancerous mice was observed. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) Activity, total antioxidant activity (T-AOC), malondialdehyde (MDA) and reduced glutathione (GSH) content. Results: Compared with the model group, the tumor formation rate and tumor diameter of high-dose lycopene group were significantly decreased, the content of MDA decreased, the activities of CAT and GSH-Px increased significantly, and the activities of SOD and T-AOC increased . Conclusion: Lycopene can inhibit tumor growth. Its mechanism may be related to increasing antioxidant enzyme activity and reducing lipid peroxidation products.