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目的探讨p53、癌胚抗原(CEA)在胃黏膜上皮内瘤变及胃癌中的表达及其临床意义。方法应用免疫组织化学方法(S-P法)检测40例正常胃黏膜、68例胃黏膜低级别上皮内瘤变、60例胃黏膜高级别上皮内瘤变以及80例胃癌中p53、CEA的表达情况。结果正常胃黏膜组p53、CEA均为阴性表达;p53在胃黏膜低级别上皮内瘤变组阳性表达率为17.65%,明显低于胃黏膜高级别上皮内瘤变组(40.00%,P<0.05)和胃癌组(56.25%,P<0.05)。CEA在胃黏膜低级别上皮内瘤变组阳性表达率为36.76%,明显低于胃黏膜高级别上皮内瘤变组(68.33%,P<0.05)和胃癌组(82.50%,P<0.05)。p53、CEA共同表达在胃黏膜低级别上皮内瘤变组为14.70%,明显低于胃黏膜高级别上皮内瘤变组(31.67%,P<0.05)和胃癌组(45.00%,P<0.05)。结论p53和CEA与胃癌关系密切,对胃黏膜上皮内瘤变联合检测p53和CEA,有助于发现早期胃癌。
Objective To investigate the expression and clinical significance of p53, carcinoembryonic antigen (CEA) in gastric intraepithelial neoplasia and gastric cancer. Methods The expressions of p53 and CEA in 40 cases of normal gastric mucosa, 68 cases of low-grade gastric intraepithelial neoplasia of gastric mucosa, 60 cases of high-grade intraepithelial neoplasia of gastric mucosa and 80 cases of gastric cancer were detected by immunohistochemistry (S-P method). Results The positive expression rate of p53 and CEA in normal gastric mucosa was negative, while the positive rate of p53 in gastric mucosal low-grade intraepithelial neoplasia was 17.65%, which was significantly lower than that in high-grade gastric intraepithelial neoplasia (40.00%, P <0.05 ) And gastric cancer group (56.25%, P <0.05). The positive rate of CEA in gastric mucosal low grade intraepithelial neoplasia group was 36.76%, which was significantly lower than that in high grade gastric intraepithelial neoplasia group (68.33%, P <0.05) and gastric cancer group (82.50%, P <0.05). The expression of p53 and CEA in gastric mucosal low-grade intraepithelial neoplasia group was 14.70%, which was significantly lower than that in gastric mucosa high-grade intraepithelial neoplasia group (31.67%, P <0.05) and gastric cancer group (45.00%, P <0.05) . Conclusion The relationship between p53 and CEA is closely related to gastric cancer. Combined detection of p53 and CEA in gastric intraepithelial neoplasia is helpful for the detection of early gastric cancer.