目的进一步探讨洛赛克、西沙比利、硫糖铝治疗症状性胃食管反流的疗效。方法采用双盲对照研究方法，对１９４例症状性胃食管反流患者分组服用洛赛克、西沙比利、硫糖铝进行４周观察治疗，根据患者症状发作的频度、程度于完成治疗的第２、４周进行药物疗效评估。结果洛赛克治疗组症状缓解率分别为３７５％、７１６％，较西沙比利治疗组６５％、３５１％有显著性差异（Ｐ＜００５），但４周后的总有效率前者９４６％与后者７６６％差异并不显著（Ｐ＞００５）。两组间的症状缓解率和总有效率均较硫糖铝治疗组７０％、３９６％有非常显著性差异（Ｐ＜００１）。结论洛赛克和西沙比利均是治疗症状性胃食管反流的有效药物，其近期疗效洛赛克优于西沙比利 Objective To investigate the efficacy of Losec, cisapride and sucralfate in the treatment of symptomatic gastroesophageal reflux disease. Methods A total of 194 patients with symptomatic gastroesophageal reflux disease were treated with Losec, cisapride and sucralfate for 4 weeks by double-blind controlled study. According to the frequency and degree of the onset of symptoms, The first two weeks 2,4 for drug efficacy evaluation. Results The symptom relief rate of Losec group was 375% and 716%, respectively, which was significantly different from that of cisapride group (6.5% and 351%, P <005) The total effective rate after the week 94.6% and the latter 76.6% difference was not significant (P> 0  05). Symptomatic remission rate and total effective rate between the two groups were significantly different from those of sucralfate treatment group (70%, 396%, P <001). Conclusions Both Losec and cisapride are effective drugs for the treatment of symptomatic gastroesophageal reflux. The recent efficacy of Losec is superior to that of cisapride