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本文报告17例中度和较严重高血压患者,应用心得安、苯氧苄胺和双氢氯噻嗪联合治疗的降压效果和副作用。患者年龄36～69岁,无心、肾功能不全、慢性阻塞性肺病或哮喘。9例最初单用心得安治疗,从20毫克每日4次开始,根据脉率和血压反应选定剂量,最大为每日160毫克,共4～12周;血压均未恢复正常。17例联用心得安和苯氧苄胺每日20～50毫克3～10周,12例卧位血压和15例立位血压恢复正常(≤150/90毫米汞柱)或接近正常(≤150/100毫米汞柱)。加用双氢氯噻嗪每日50～100毫克,同时减少苯氧苄胺剂量后,立、卧位血压下降更为显著,全部恢复正常或接近正常。β受体阻滞剂用于治疗高血压已经多年,但单用的效果报告颇不一致。作者认为单用上述剂量心得安
This article reports 17 patients with moderate and severe hypertension, the application of propranolol, phenoxybenzamine and hydrochlorothiazide combined antihypertensive effect and side effects. Patients aged 36 to 69 years, unintentional, renal insufficiency, chronic obstructive pulmonary disease or asthma. Nine patients initially treated with propranolol alone, starting from 20 mg 4 times a day, according to the selected dose of pulse rate and blood pressure response, the maximum daily 160 mg, a total of 4 to 12 weeks; blood pressure did not return to normal. 17 cases of combination of phenoxybenzamine and phenoxybenzamine daily 20 to 50 mg for 3 to 10 weeks, 12 cases of supine pressure and 15 cases of standing blood pressure returned to normal (≤ 150/90 mm Hg) or near normal (≤ 150 / 100 mmHg). Hydrochlorothiazide plus 50 to 100 mg per day, while reducing the dose of phenoxybenzamine, legislation, declining blood pressure was more significant decline, all returned to normal or near normal. Beta-blockers have been used for many years in the treatment of hypertension, but the report of the effect alone is quite inconsistent. The authors believe that alone with the above dose propofol