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目的观察原发性肾病综合征(NS)患者体内血小板活化状态。方法采用酶联免疫吸附法(ELISA)检测36例NS患者血浆11-去氢-血栓烷B2(DH-TXB2),同时测定TXB2,并与对照组比较。结果与对照组比较,两组NS患者血浆DH-TXB2,TXB2均显著增高,且DH-TXB2增高程度明显高于TXB2,两组经治疗后难治性肾病组血浆DH-TXB2,TXB2无显著降低,而激素敏感组DH-TXB2、TXB2均显著降低,但仍高于对照组。经相关分析,血浆DH—TXB2,TXB2均与血浆ALB呈负相关,24小时尿蛋白定量呈正相关。结论 血浆DH-TXB2水平测定是准确反映体内血小板活化的指标,NS患者体内血小板高度活化。
Objective To observe the activation of platelet in patients with primary nephrotic syndrome (NS). Methods The plasma levels of 11-dehydro-thromboxane B2 (DH-TXB2) in 36 patients with NS were measured by enzyme-linked immunosorbent assay (ELISA) Results Compared with the control group, the plasma levels of DH-TXB2 and TXB2 in both NS patients were significantly increased, and the increased levels of DH-TXB2 were significantly higher than those of TXB2. The plasma levels of DH-TXB2 and TXB2 in the two groups of NS patients were not significantly decreased , While the hormone-sensitive group DH-TXB2, TXB2 were significantly lower, but still higher than the control group. Correlation analysis showed that plasma DH-TXB2 and TXB2 were negatively correlated with plasma ALB and positively correlated with 24-hour urinary protein. Conclusion The determination of plasma DH-TXB2 level is an accurate indicator of platelet activation in vivo. High platelet activation is observed in NS patients.