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目的探讨窒息新生儿出凝血功能变化的临床意义。方法检测40例窒息新生儿及16例正常新生儿的PT、APTT、Fg、PLT、AT-Ⅲ、PC、D-D。结果轻度窒息组PT、APTT、Fg、PLT差异无统计学意义(P>0.05),重度窒息组PT、APTT、Fg、PLT差异有统计学意义(P<0.01),表现为PT、APTT延长,PLT、Fg降低;轻度窒息组与重度窒息组APTT-Ⅲ、PC、D-D差异有统计学意义(P<0.05,P<0.01),均表现为AT-Ⅲ、D-D增高,PC降低,重度窒息组较轻度窒息组更为明显(P<0.01)。结论窒息新生儿存在出凝血功能紊乱,表现为以高凝状态为主的Pred-DIC.
Objective To investigate the clinical significance of changes in coagulation function in neonates with asphyxia. Methods PT, APTT, Fg, PLT, AT-Ⅲ, PC and D-D in 40 neonates with asphyxia and 16 normal neonates were detected. Results There was no significant difference in PT, APTT, Fg and PLT in mild asphyxia group (P> 0.05), PT, APTT, Fg and PLT in severe asphyxia group were statistically significant (P <0.01) (P <0.05, P <0.01), all of which showed increased AT-Ⅲ and DD, decreased PC, severe and severe asphyxia group Asphyxia group was more obvious than mild asphyxia group (P <0.01). Conclusion There are coagulation disorders in neonates with asphyxia, manifested as Pred-DIC with predominantly hypercoagulable state.