大鼠心、肾α１肾上腺素能受体与呱唑嗪结合能力在不同浓度的Ｎａ＋中，呈现不同的反应。肾脏的α１受体在低浓度Ｎａ＋时（１３０ｍｍｏｌ／Ｌ），其Ｂｍａｘ和Ｋｄ均明显升高（Ｐ＜０．０５）；心肌无明显变化。在高浓度Ｎａ＋时（１５０ｍｍｏｌ／Ｌ），心肌的α１受体结合容量明显下降（Ｐ＜０．０１）。提示：Ｎａ＋对具α１受体以结合抑制配基的能力可能有直接调节作用；心肌和肾脏α１受体以不同的亚型为主，对Ｎａ＋应答存在差异。 Rat heart, kidney α1 adrenergic receptor and prazosin binding ability in different concentrations of Na +, showed a different response. The α1 receptor in kidneys was significantly increased at low concentrations of Na + (130mmol / L), while the Bmax and Kd were significantly increased (P <0.05). At high concentration of Na + (150 mmol / L), the binding capacity of α1 receptor in myocardium decreased significantly (P <0.01). It is suggested that Na + may have a direct regulatory effect on the ability of the α1 receptor to bind to inhibit ligands. The α1 receptors in myocardium and kidney are mainly subtypes with different responses to Na +.