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迄今为止,儿童单纯性肾病的发病机理尚不十分清楚。近几年来,人们从临床及实验室检查等方面发现,该病的发病常常与过敏因素有关;另有研究表明,组胺不仅是炎症反应和免疫损伤的重要介质之一,而且对免疫应答和炎症反应有重要的调节作用。鉴此,我们测定了近一年多来单纯性肾病患儿尿组胺类物质含量,以探讨组胺与肾病发病的关系及其临床意义。材料和方法一、对象:单纯性肾病患儿18例(49例次),年龄3～13岁,男12例,女6例,分别于发作期和/或缓解期测定尿组胺类物质含量。健康儿童46例作正常对照。过敏性紫瘢性肾炎患儿10例(17例次)作疾病对照。
So far, the pathogenesis of childhood simple nephropathy is not yet clear. In recent years, people from clinical and laboratory tests found that the incidence of the disease are often associated with allergic factors; another study shows that histamine is not only one of the important inflammatory mediators and immune damage, but also on the immune response and Inflammation has an important regulatory role. In view of this, we measured the urinary histamine content of children with simple nephropathy in the past year or so to explore the relationship between histamine and nephropathy and its clinical significance. Materials and Methods First, the object: 18 cases of simple nephrotic syndrome (49 cases), aged 3 to 13 years old, 12 males and 6 females, respectively, in the onset and / or remission of urine histamine content . 46 healthy children as normal control. Allergic purpura nephritis in 10 cases (17 cases) as a disease control.