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目的通过对复发性流产夫妇的染色体核型分析,进一步了解染色体核型异常对复发性流产的影响。方法对1998年5月—2009年4月11年间来我院的1558对(3116例)复发性流产夫妇进行外周血染色体核型分析。结果检出异常核型178例,总异常率:5.7%(178/3116)。女性异常49例,其中数目异常1例,结构异常39例,染色体多态性9例。男性异常129例,其中数目异常1例,结构异常19例,染色体多态性109例。结论染色体异常是复发性流产的主要原因,在流产夫妇中行染色体检查对指导再次妊娠有重要意义。
Objective To further understand the effect of chromosomal abnormalities on recurrent spontaneous abortion by analyzing the karyotypes of recurrent spontaneous abortion couples. Methods A total of 1558 recurrent spontaneous abortion couples who came to our hospital from May 1998 to April 2009 were analyzed for karyotype of peripheral blood. Results 178 cases of abnormal karyotype detected, the total abnormal rate: 5.7% (178/3116). There were 49 cases of abnormal women, of which 1 was abnormal in number, 39 were abnormal in structure, and 9 were chromosomal polymorphisms. 129 cases of abnormal male, of which an abnormal number in 1 case, 19 cases of structural abnormalities, 109 cases of chromosomal polymorphisms. Conclusions Chromosomal abnormalities are the main cause of recurrent spontaneous abortion. It is of great importance to conduct chromosomal examination in abortion couples to guide pregnancy again.