论文部分内容阅读
目的提高对肺上皮样血管内皮瘤(PEHE)临床病理特征以及遗传学特点的认识。方法应用HE染色、免疫组化方法对伴纵隔B3型胸腺瘤的临床病理特征、免疫表型进行分析,并结合文献讨论。结果 PEHE好发于中年女性,临床无特异性症状,影像学检查表现为肺内多发或孤立性病灶;镜下显示黏液样或玻璃样变的背景中瘤细胞呈短索状或小巢状排列,可见胞质内空泡;肿瘤细胞表达血管内皮标记。结论肺上皮样血管内皮瘤少见,无特异性临床表现,诊断主要依靠组织病理学和免疫组化检查。
Objective To improve the clinicopathological features and genetic characteristics of pulmonary epithelioid hemangioendothelioma (PEHE). Methods The clinicopathological features and immunophenotypes of mediastinal type B3 thymoma were analyzed by HE staining and immunohistochemistry. Results PEHE occurred in middle-aged women, no specific clinical symptoms, imaging showed multiple intracranial pulmonary or isolated lesions; microscopy showed mucoid or hyaline changes in the background of tumor cells were short cord or small nests Arranged, visible cytoplasmic vacuoles; tumor cells express vascular endothelial markers. Conclusions Pulmonary epithelioid hemangioendothelioma is uncommon and has no specific clinical manifestations. The diagnosis mainly depends on histopathology and immunohistochemistry.