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目的:观察运动干预结合雌激素补充对绝经早期妇女骨密度的影响。方法:将120例绝经早期妇女随机分为综合组、雌激素组和对照组,综合组每日口服利维爱+钙尔奇D,并进行有氧运动训练(3次/周,1 h/次);雌激素组每日口服利维爱+钙尔奇D,对照组每日口服钙尔奇D。于治疗前、治疗12个月后分别测定第2～4腰椎(L2～4)骨密度(BMD)、血清骨钙素(BGP)、尿吡啶啉(U-Pyd/Cr),以及全身疼痛改善情况和子宫内膜变化情况。结果:治疗12个月后综合组和雌激素组的腰椎总BMD分别较治疗前增加了21.04%(P<0.05)和12.98%(P<0.05),血清BGP分别升高40.59%(P<0.05)和34.25%(P<0.05),U-Pyd/Cr分别下降32.28%(P<0.05)和21.71%(P<0.05),两组比较差异均有统计学意义(P<0.05)。两治疗组各项指标较对照组均有显著变化(P<0.05)。综合组与雌激素组疼痛改善率较对照组显著(P<0.05)。3组子宫内膜治疗前后无明显变化。结论:运动干预结合雌激素补充能有效提高绝经早期妇女骨密度。
Objective: To observe the effects of exercise intervention and estrogen supplement on the bone mineral density in early menopause women. Methods: A total of 120 premenopausal women were randomly divided into the combined group, the estrogen group and the control group. The combination group was orally administered with Levi and Calcium D daily for aerobic exercise training (3 times / week for 1 h / Times). The estrogen group was orally administered with Levi + Calcium D daily, and the control group was orally administered with calcium daily. Bone mineral density (BMD), serum BGP, U-Pyd / Cr, and overall body pain were measured at the second to fourth lumbar spine (L2 ~ 4) Situation and endometrial changes. Results: The BMD of lumbar vertebrae in the combination group and the estrogen group increased by 21.04% (P <0.05) and 12.98% (P <0.05), and the serum BGP levels increased by 40.59% (P <0.05) ) And 34.25% respectively (P <0.05). U-Pyd / Cr decreased 32.28% (P <0.05) and 21.71% (P <0.05) respectively. There was significant difference between the two groups (P <0.05). The two indicators of the treatment group than the control group had significant changes (P <0.05). The improvement rate of pain in combination group and estrogen group was significantly higher than that in control group (P <0.05). There was no significant change in 3 groups before and after treatment of endometrium. Conclusion: Exercise intervention combined with estrogen replacement can effectively improve the bone mineral density in early postmenopausal women.