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目的 评价全程加速超分割放射治疗食管癌的疗效。方法 2 16例食管鳞癌病例随机分为 2个组 :⑴常规分割组 (CF) 110例 ,方法为 2Gy/次 ,5次 /周 ,总剂量 6 0～ 70Gy ,30～ 35分次 ,6～ 7周完成 ;⑵全程加速超分割组 (WCAHF) 10 6例 ,方法为 1.5Gy/次 ,2次 /d ,间隔 6h以上 ,总剂量 5 1～ 6 0Gy,34～ 40分次 ,3.3～ 4.0周完成。结果 CF组和WCAHF组的 1、3、5年生存率分别为 45 .5 %和6 9 .8%、2 0 .0 %和 40 .6 %、13.6 %和 33.0 % ,全程加速超分割组明显优于常规组 ,2个组差异有极显著性意义 (P <0 .0 1) ;而放射治疗副反应和并发症 2个组差异无显著性意义 (P >0 .0 5 )。结论 全程加速超分割放射治疗能明显提高食管癌患者的长期生存率 ,不明显增加放射治疗副反应及并发症
Objective To evaluate the efficacy of accelerated hyperfractionation radiotherapy for esophageal cancer. Methods Twenty-six cases of esophageal squamous cell carcinoma were randomly divided into two groups: (1) 110 cases of conventional CF, 2Gy / time, 5 times / week, total dose of 60-70Gy, 30-35 times, 6 ~ 7 weeks to complete; ⑵ full accelerated grouping (WCAHF) 106 cases, the method is 1.5Gy / times, 2 times / d, more than 6h intervals, the total dose of 51 ~ 60Gy, 34 ~ 40 times, 4.0 weeks to complete. Results The 1, 3, 5-year survival rates of CF group and WCAHF group were 45.5% and 69.8%, 20.0% and 40.6%, 13.6% and 33.0%, respectively. The overall accelerated hyperfractionation group The difference between the two groups was significant (P <0.01). There was no significant difference between the two groups in side effects and complications of radiotherapy (P> 0.05). Conclusion Accelerated hyperfractionated radiation therapy can significantly improve the long-term survival rate of patients with esophageal cancer without significantly increasing the side effects and complications of radiation therapy