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目的探讨α-L-岩藻糖苷酶(AFU)和总胆固醇(TC)在恶性腹水和非结核性良性腹水鉴别诊断价值。方法应用半自动生化分析仪对221例腹水进行AFU活性和TC测定。结果恶性腹水AFU和TC为(173.89±92.40)μmol.L-1.h-1和(1.69±0.98)mmol/L,明显高于非结核性良性腹水的(103.07±57.11)μmol.L-1.h-1和(0.70±0.60)mmol/L(P<0.01)。以AFU120μmol.L-1.h-1和TC1.1mmol/L为界值,恶性腹水的敏感性分别为67.65%和75.63%,特异性分别为72.55%和85.71%;两项联合检测的敏感性、特异性为77.45%、91.59%。结论腹水AFU、TC的活性测定有助于恶性腹水和非结核性良性腹水鉴别诊断;两者联合检测可提高鉴别诊断的敏感性和特异性。
Objective To investigate the differential diagnostic value of α-L-fucosidase (AFU) and total cholesterol (TC) in malignant ascites and non-tuberculous benign ascites. Methods 221 cases of ascites were tested for AFU activity and TC by semi-automatic biochemical analyzer. Results The AFU and TC of malignant ascites were (173.89 ± 92.40) μmol.L-1.h-1 and (1.69 ± 0.98) mmol / L, respectively, which were significantly higher than those of non-tuberculous benign ascites (103.07 ± 57.11) μmol.L- .h-1 and (0.70 ± 0.60) mmol / L (P <0.01). The sensitivity of malignant ascites was 67.65% and 75.63% with specificity of 72.55% and 85.71%, respectively, with the limits of AFU120μmol.L-1.h-1 and TC1.1mmol / L. The sensitivity of the two combined assays , The specificity was 77.45%, 91.59%. Conclusion Ascites AFU, TC activity determination is helpful for the differential diagnosis of malignant ascites and non-tuberculous benign ascites; The combination of both can improve the sensitivity and specificity of differential diagnosis.