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目的 :探讨血管紧张素转换酶 ( ACE)基因多态性对高血压病 ( EH)患者左室肥厚与重构的影响。方法 :对 68例 EH患者进行超声心动图检查 ,测定左室重量指数 ( L VMI)和室壁相对厚度( RWT) ,并从外周血白细胞中抽提人类基因组脱氧核糖核酸 ( DNA) ,应用 ACE基因第 16内含子多态区两侧序列作为引物 ,聚合酶链式反应测定 ACE基因型。结果 :经纠正其他因素影响后 ,DD型患者 L VMI和室壁相对厚度均高于 II型患者 ( P <0 .0 5 ) ,经多元线性逐步回归分析 ,收缩期血压、性别、ACE基因型均与 LVMI独立相关 (总 R2 =0 .36) ,而收缩期血压、体重指数、ACE基因型均与 RWT独立相关 (总 R2 =0 .49)。结论 :ACE基因型分别可解释 LVMI和 RWT总变异的 3.8%和 2 .0 % ,ACE基因 DD型可能是中国汉族 EH患者左室肥厚与重构的新的独立危险因素 ,应重视此类患者的防治。
Objective: To investigate the effect of angiotensin converting enzyme (ACE) gene polymorphism on left ventricular hypertrophy and remodeling in patients with essential hypertension (EH). Methods: Echocardiography was performed in 68 patients with EH. Left ventricular mass index (LVMI) and relative wall thickness (RWT) were measured. Human genomic DNA was extracted from peripheral blood leukocytes. The ACE gene The 16th intron polymorphism region on both sides of the sequence as a primer, polymerase chain reaction ACE genotype. Results: After correcting for the other factors, the L VMI and the relative wall thickness of type DD patients were higher than those of type II patients (P <0.05). The multivariate linear stepwise regression analysis showed that systolic blood pressure, gender and ACE genotype Independent of LVMI (total R2 = 0.36), whereas systolic blood pressure, body mass index, and ACE genotype were independently associated with RWT (total R2 = 0.49). CONCLUSIONS: ACE genotypes account for 3.8% and 2.0% of the total variance of LVMI and RWT, respectively. DD genotype of ACE gene may be a new independent risk factor for left ventricular hypertrophy and remodeling in Chinese Han patients with EH, and attention should be paid to these patients Prevention and treatment.