,Genome-Wide DNA Binding of GBF1 Is Modulated by Its Heterodimerizing Protein Partners, HY5 and HYH

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Dear Editor,In todays post-genomic era where direct targets of many transcription factors have been identified,it is becoming increasingly evident that transcriptional networks are very complex.Heterodimerization of transcription factors is one of the several methods by which these complex transcriptional networks are formed.By heterodimerization,DNA-binding specificity and affinity,transactivation properties,and ultimately cell physiology might be altered (Naar et al.,2001).The formation of heterodimers has the potential to recognize additional binding sites and increase the range of DNA-binding specificity (Foster et al.,1994).Further,heterodimerization also allows the production of new protein configurations.
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