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接触噪声1、4、8周(W)后,敏感型大鼠(A类)下丘脑CGRP含量明显低于A类对照组。暴露8W后,不敏感型大鼠(B类)接触组下丘脑CGRP含量也明显低于B类大鼠对照组。本研究还观察到噪声接触4、8W后,A、B类反应大鼠接触组大脑皮层中CGRP含量均明显低于各自对照组。接触8W后,A类反应大鼠接触组血浆中CGRP浓度明显低于A类反应对照组。以下丘脑为主的CGRP含量降低早于血压升高(8W后升高),所以它有可能参与噪声作用下对血压的调节
After 1, 4 and 8 weeks of exposure to noise, the content of CGRP in the hypothalamus of the sensitive rats (A type) was significantly lower than that of the A type control rats. After exposure to 8W, the content of CGRP in the hypothalamus of the non-sensitive rats (type B) exposed group was also significantly lower than that of the type B rat control group. This study also observed that after exposure to noise for 4 and 8 W, the levels of CGRP in the cerebral cortex of rats exposed to A, B reaction were significantly lower than those of the control group. After exposure to 8W, the concentration of CGRP in plasma of Group A rats was significantly lower than that of Type A control rats. The hypothalamus-predominant CGRP decreased earlier than the blood pressure (increased after 8 weeks), so it is likely to be involved in the regulation of blood pressure under noise