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乙型肝炎抗原和抗体 1970年Dane等发现在HBAg阳性的血清中有一种直径为42毫微米的颗粒。进一步研究发现Dane颗粒具有7毫微米厚的外壳和28毫微米直径的核心。免疫电镜检查发现,抗HBAg抗体亦可凝集Dane颗粒及直径20毫微米的球形或管形颗粒,证明这三种颗粒具有共同之表面抗原,因而改称乙型肝炎表面抗原(HBsAg)。另外Almeida等用除垢剂处理Dane颗粒后,释出核心抗原(HBcAg),并在一例肝炎恢复期病人抗HBsAg抗体阴性的血清中,用
Hepatitis B Antigen and Antibodies Dane et al found in 1970 that there was a 42 nm diameter particle in HBAg-positive serum. Further studies revealed that the Dane particles have a 7 nm shell and a 28 nm diameter core. Immuno-electron microscopy revealed that the anti-HBAg antibody also agglutinated Dane particles and spherical or tubular particles of 20 nm in diameter, demonstrating that the three particles share a common surface antigen and thus are renamed as hepatitis B surface antigen (HBsAg). In addition, Almeida and other detergents treated with Dane particles, the release of core antigen (HBcAg), and in a patient recovering from hepatitis B anti-HBsAg antibody-negative serum with