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目的:建立一种磷酸可待因非法添加的化学快检方法。方法:以拟定的快检方法作为初筛方法,高分离度快速液相四极杆串联飞行时间质谱法(RRLC-QTOF-MS)作为最终确证方法。结果:30批样品阳性检出率为100%,假阴性为0%,真阴性率为89.3%,假阳性率为10.7%,方法的检测灵敏度为0.12 mg。结论:该化学快检方法专属性强,灵敏度高,可提高抽样命中率,对磷酸可待因的非法添加起到监督作用。
OBJECTIVE: To establish a chemical fast detection method of adding codeine phosphate illegally. Methods: The proposed rapid screening method as a screening method, high resolution fast liquid quadrupole tandem time of flight mass spectrometry (RRLC-QTOF-MS) as the final confirmation method. Results: The positive detection rate was 100%, the false negative rate was 0%, the true negative rate was 89.3% and the false positive rate was 10.7%. The detection sensitivity was 0.12 mg. Conclusion: This method is characterized by high specificity and high sensitivity, which can improve the sampling hit rate and play an supervisory role in the illegal addition of codeine phosphate.