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用紫苏(Perillta frutescens)叶中挥发油主要化学成分不同的五种类型紫苏,紫苏醛型、l-苎烯型、肉豆蔻醚型、香薷酮型和紫苏酮型的甲醇提取物对小鼠进行增强小肠推进力(IP)的药理试验。结果仅紫苏酮型提取物,在口服剂量1g/kg 时有显著的IP 增强作用,即使低剂量0.25 g/kg 时仍有活性。此提取物经分离、提取、硅胶柱层析,分别用正己烷-丙酮(10:1)和(50:1)洗脱,得一组分164 mg,呈最强活性。经GLC、UV、IR 和’H-NMR 测试确证该组分为紫苏酮。
Five kinds of perilla frutescens (Perillta frutescens) leaf volatile oil main chemical composition of different types of basil, perillaldehyde type, l-limonene type, myristicin type, sesbanone and perilla ketone type methanol extract pairs Mice undergo pharmacological tests to enhance small bowel propulsion (IP). Results Perilla ketone-only extract showed significant IP enhancement at an oral dose of 1 g / kg, with activity even at low doses of 0.25 g / kg. The extract was separated, extracted, and purified by silica gel column chromatography, eluted with n-hexane-acetone (10: 1) and (50: 1) respectively. The components were confirmed to be Perilla ketone by GLC, UV, IR and ’H-NMR tests.