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目的检测干细胞标记物Oct4蛋白在胃癌组织及其相应癌旁组织中的表达,并探讨其与临床病理因素的相关性。方法收集54例患者手术切除的胃癌组织及对应的癌旁组织标本,应用免疫组织化学方法检测Oct4蛋白的表达。结果胃癌组织Oct4蛋白阳性表达率显著高于癌旁组织(75.9%vs.33.3%)(P<0.05);胃癌组织中Oct4蛋白的表达与肿瘤分化程度呈正相关(P<0.05),亦与胃癌的浸润深度、淋巴结转移密切相关(P<0.05),但与年龄、性别、TNM分期无关。结论胃癌组织中Oct4蛋白的表达与肿瘤分化程度相关,Oct4可以作为胃癌预后判断有价值的分子标记物。
Objective To detect the expression of stem cell marker Oct4 in gastric cancer tissues and its corresponding paracancerous tissues and to explore its correlation with clinicopathological factors. Methods Collected 54 cases of gastric cancer tissues and corresponding paracancerous tissue specimens, immunohistochemical detection of Oct4 protein expression. Results The positive rate of Oct4 protein in gastric cancer tissues was significantly higher than that in adjacent non-cancerous tissues (75.9% vs.33.3%, P <0.05). The expression of Oct4 protein in gastric cancer tissues was positively correlated with tumor differentiation (P <0.05) Depth of invasion, lymph node metastasis (P <0.05), but not with age, gender, TNM stage. Conclusion The expression of Oct4 protein in gastric cancer is correlated with the degree of tumor differentiation. Oct4 can be used as a valuable molecular marker in the prognosis of gastric cancer.