The spatial variability of input ground motion at supporting foundations plays a key role in the structural response of cable-stayed bridges (CSBs); therefore, spatial variation effects should be included in the analysis and design of effective vibration control systems. The control of CSBs represents a challenging and unique problem, with many complexities in modeling, control design and implementation, since the control system should be designed not only to mitigate the dynamic component of the structural response but also to counteract the effects of the pseudo-static component of the response. The spatial variability effects on the feasibility and efficiency of seismic control systems for the vibration control of CSBs are investigated in this paper. The assumption of uniform earthquake motion along the entire bridge may result in quantitative and qualitative differences in seismic response as compared with those produced by uniform motion at all supports. A systematic comparison of passive and active system performance in reducing the structural responses is performed, focusing on the effect of the spatially varying earthquake ground motion on the seismic response of a benchmark CSB model with different control strategies, and demonstrates the importance of accounting for the spatial variability of excitations. The spatial variability of input ground motion at supporting foundations plays a key role in the structural response of cable-stayed bridges (CSBs); therefore, spatial variation effects should be included in the analysis and design of effective vibration control systems. The control of CSBs representing a challenging and unique problem, with the complex complex in modeling, control design and implementation, since the control system should be designed not only to mitigate the dynamic component of the structural response but also to counteract the effects of the pseudo-static component of the response. The spatial variability effects on the feasibility and efficiency of seismic control systems for the vibration control of CSBs are investigated in this paper. The assumption of uniform earthquake motion along the entire bridge may result in quantitative and qualitative differences in seismic response as compared with those produced by uniform motion at all supports. A systematic comparison of passive and active system performance in reducing the structural responses is performed, focusing on the effect of the spatially varying earthquake ground motion on the seismic response of a benchmark CSB ​​model with different control strategies, and demonstrates the importance of accounting for the spatial variability of excitations .