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目的观察焦点黏附激酶(FAK)在不同肝癌组织中表达差异及 FAK 表达在判断肝细胞癌预后中的意义。方法回顾性分析了我所50例肝细胞癌患者临床资料。利用实时 PCR 法检测了肿瘤组织和癌周组织中 FAK mRNA 表达,并分析了 FAK mRNA 表达与肝细胞癌临床病理及预后的关系。结果 FAK mRNA 在肿瘤组织中的表达明显高于癌周组织表达(P<0.001),癌栓组中癌栓中 FAK mRNA 表达高于肿瘤组织表达(P<0.05),癌栓组中肿瘤组织 FAK mRNA 表达明显高于无癌栓组肿瘤组织表达(P=0.003)。高侵袭组中肿瘤组织 FAK mRNA 表达明显高于低侵袭组表达(P=0.020)。单因素与多因素分析发现 FAK 表达是影响肝细胞癌术后生存率的独立因素。结论 FAK在肝细胞癌发生、发展中有重要作用,FAK 表达是肝细胞癌预后指标之一。
Objective To observe the difference of focal adhesion kinase (FAK) expression in different liver cancer tissues and the significance of FAK expression in the prognosis of hepatocellular carcinoma. Methods The clinical data of 50 patients with hepatocellular carcinoma in our hospital were retrospectively analyzed. Real-time PCR was used to detect the expression of FAK mRNA in tumor tissues and pericancerous tissues. The relationship between FAK mRNA expression and the clinicopathologic features and prognosis of hepatocellular carcinoma was analyzed. Results The FAK mRNA expression in tumor tissue was significantly higher than that in peritumor tissue (P <0.001). The expression of FAK mRNA in tumor thrombus in tumor thrombus group was higher than that in tumor tissue (P <0.05). The FAK mRNA expression was significantly higher than tumor tissue without tumor embolus (P = 0.003). The expression of FAK mRNA in high invasion group was significantly higher than that in low invasion group (P = 0.020). Univariate and multivariate analysis showed that FAK expression was an independent factor affecting the postoperative survival rate of hepatocellular carcinoma. Conclusion FAK plays an important role in the occurrence and development of hepatocellular carcinoma. FAK expression is one of the prognostic indicators of hepatocellular carcinoma.