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Sultamicilin(SBTPC)系由Pfizer公司研制的口服β-内酰胺类抗生素,它是一种由舒巴克坦(SulbactamSBT)及氨苄青霉素(ABPC)结合形成的酯。ABPC是临床各科广泛应用的药物,但由于临床分离菌中β-内酰胺酶产生菌株增加,以致近年来适用范围缩小;SBT作为抗菌药物单独应用很少有效,但能使β-内酰胺酶产生株不可逆的失活,故与各种β-内酰胺类合用,能增强对β-内酰胺酶产生株的抗菌活力,然而由于肠道吸收甚差,不能用于口服,仅用于注射。 SBT与ABPC结合成酯SBTPC口服后在肠道中吸收率甚高,经肠壁脂酶水解后,
Sultamicilin (SBTPC) is an oral beta-lactam antibiotic developed by Pfizer, an ester formed by the combination of Sulbactam SBT and ampicillin (ABPC). ABPC is a widely used drug in clinical departments. However, due to the increase of β-lactamase-producing strains in clinical isolates, the scope of application has been narrowed in recent years. SBT is rarely effective as an antimicrobial agent alone, Resulting in irreversible inactivation of strains, it is combined with a variety of β-lactams, can enhance the antibacterial activity of β-lactamase-producing strains, however, because the intestinal absorption is poor, can not be used orally, only for injection. SBT and ABPC combined into ester SBTPC after oral absorption rate in the intestine is very high, after hydrolysis by intestinal wall lipase,