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目的探讨外周血中性粒细胞比例评估系统性红斑狼疮(SLE)病情的应用价值。方法检测27例SLE患者(SLE组)及81例健康体检者(对照组)外周血的中性粒细胞数及其比例,分析中性粒细胞比例与狼疮活动度及狼疮肾炎的关系。结果 SLE组外周血中性粒细胞比例高于对照组[(66.29±12.00)%vs.(57.08±8.05)%](P<0.01),而两组外周血中性粒细胞数差异无统计学意义(P>0.05)。SLE组中,狼疮肾炎患者外周血中性粒细胞数及其比例高于无狼疮肾炎患者(P<0.05或P<0.01)。中性粒细胞比例与24-h尿蛋白呈正相关(r=0.382,P<0.05),中性粒细胞比例预测狼疮肾炎的灵敏度为0.824,特异度为0.800。狼疮重度活动患者中性粒细胞比例高于非重度活动患者(P<0.01),中性粒细胞比例与SLE疾病活动指数评分呈正相关(r=0.634,P<0.01)。中性粒细胞比例预测狼疮重度活动的灵敏度为0.846,特异度为0.643。结论外周血中性粒细胞比例与狼疮肾炎及狼疮活动度密切相关,可用于预测狼疮肾炎和重度活动的发生。
Objective To investigate the value of peripheral blood neutrophil ratio in the evaluation of systemic lupus erythematosus (SLE). Methods The numbers of neutrophils and their proportion in peripheral blood of 27 SLE patients and 81 healthy controls (control group) were detected. The relationship between neutrophil ratio and lupus activity and lupus nephritis was analyzed. Results The proportion of peripheral blood neutrophils in SLE group was significantly higher than that in control group [(66.29 ± 12.00)% vs (57.08 ± 8.05)%] (P <0.01), but there was no significant difference in peripheral blood neutrophil count Significance (P> 0.05). In the SLE group, the number of peripheral blood neutrophils in lupus nephritis patients and their proportion were higher than those without lupus nephritis (P <0.05 or P <0.01). Neutrophil proportion was positively correlated with 24-h urinary protein (r = 0.382, P <0.05). The sensitivity of neutrophil proportion prediction for lupus nephritis was 0.824 and the specificity was 0.800. The proportion of neutrophils in severe lupus patients was higher than that in non-severe patients (P <0.01). Neutrophil percentage was positively correlated with SLE index (r = 0.634, P <0.01). The sensitivity of the neutrophil ratio prediction for severe lupus activity was 0.846 and the specificity was 0.643. Conclusion Peripheral blood neutrophil ratio is closely related to lupus nephritis and lupus activity, which can be used to predict the occurrence of lupus nephritis and severe activity.