目的:优选抗流感口服液的提取工艺。方法:以解热药效为指标,采用药效跟踪试验考察提取溶媒和提取方式;以黄芩苷转移率为指标,采用正交试验法考察提取时间、提取次数及溶剂用量对抗流感口服液提取工艺的影响。结果:最佳提取工艺为加12倍量水提取3次,每次1 h,黄芩苷转移率85.41%。结论:采用药效跟踪试验可保障产品的有效性,优选的提取工艺稳定、可行、操作性强。 Objective: To optimize the extraction process of anti-flu oral liquid. Methods: With antipyretic efficacy as an indicator, the effects of solvent extraction and extraction methods were investigated by follow-up test. The extraction rate of baicalin was calculated by orthogonal test. The extraction time, the number of extraction and the amount of solvent were investigated. Impact. Results: The optimal extraction process was extraction of 12 times the amount of water three times, each time 1 h, baicalin transfer rate of 85.41%. Conclusion: The efficacy of follow-up test to protect the effectiveness of the product, the preferred extraction process is stable, feasible and operational.