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目的探讨腹腔镜和开腹完整肠系膜切除术对结肠癌患者术后相关肿瘤生物学行为的影响。方法以2013年7月至2015年1月在我院进行手术医治的80例结肠癌患者为研究对象,依据术式的不同将所研究对象分为腹腔镜组和开放组,各40例,采集患者的腹腔冲洗液和外周静脉血,对冲洗液中增值调节分子、血清肿瘤标志分子以及免疫分子的含量进行比较分析。结果开放组腹腔冲洗液P16和DCL-1含量较腹腔镜组低,而Cyclin D1、CDK4、P-gp、MDR-1含量确比腹腔镜高(P<0.05);开放组患者血清中结肠癌CCSA-2、3′sulfo-Lewis、Annexin-A5、MK、PTN、SIL-2R含量均较腹腔镜组高(P<0.05);血清中HAb18G、CD147,Lgr5,CD40,CD34,D2-40的m RNA含量开放组均明显低于腹腔镜组(P<0.05)。结论腹腔镜手术对肿瘤的增值不仅具有抑制作用,还可减少肿瘤标志分子释放、增加机体免疫分子的含量。
Objective To investigate the effect of laparoscopic and open complete mesenteric excision on the biological behavior of colon cancer patients after surgery. Methods From July 2013 to January 2015 in our hospital for surgery in 80 cases of colon cancer patients as the research object, according to different surgical procedures will be divided into laparoscopic group and open group, 40 cases each, collected The patient’s peritoneal wash fluid and peripheral venous blood, rinse fluid value-added regulatory molecules, serum tumor markers and immune molecules were compared. Results Compared with laparoscopic group, the content of P16 and DCL-1 in peritoneal wash fluid of open group was lower than that of laparoscopic group, while the contents of Cyclin D1, CDK4, P-gp and MDR-1 in laparoscopic group were significantly higher than those in laparoscopic group (P <0.05) The levels of CCSA-2, 3’sulfo-Lewis, Annexin-A5, MK, PTN and SIL-2R in laparoscopic group were significantly higher than those in laparoscopic group The content of m RNA in open group was significantly lower than that in laparoscopic group (P <0.05). Conclusion Laparoscopic surgery can not only inhibit the proliferation of tumor, but also reduce the release of tumor marker molecules and increase the content of immune molecules.