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以10名慢阻肺继发性肺动脉高压患者和10名健康人为对象,采用右心漂浮导管的实验方法并应用放免技术,观察了肺血流动力学、动脉血气各指标和TXB_2、6-KPGF_(1α)的相关性。结果表明:慢阻肺患者血浆TXB_2水平高于健康人,6-KPGF_(1α)低于对照组,TXB_2/6-KPGF_(1α)比值明显升高。PAMP与血浆TXB_2、TXB_2/6-KPGF_(1α)比值呈正相关。PaO_2与TXB_2、TXB_2/6-KPGF_(1α)呈负相关,与6-KPGF_(1α)呈正相关。提示慢阻肺可能由于低氧使TXB_2/6-KPGF_(1α)比值升高,后者可能是收缩肺血管、引起肺动脉高压的因素之一。
Ten patients with COPD and 10 healthy subjects were enrolled in this study. Right ventricular floating catheter was used in the experiment and radioimmunoassay was used to observe the changes of pulmonary hemodynamics, arterial blood gas, TXB_2, 6-KPGF_ (1α). The results showed that the plasma level of TXB_2 in COPD patients was higher than that in healthy people, and the ratio of TXB_2 / 6-KPGF_ (1α) was significantly higher than that of 6-KPGF_ (1α) in control subjects. PAMP and plasma TXB_2, TXB_2 / 6-KPGF_ (1α) ratio was positively correlated. PaO_2 was negatively correlated with TXB_2, TXB_2 / 6-KPGF_ (1α) and positively correlated with 6-KPGF_ (1α). It is suggested that chronic obstructive pulmonary disease may increase the ratio of TXB_2 / 6-KPGF_ (1α) due to hypoxia, which may be one of the factors of pulmonary hypertension and pulmonary hypertension.