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目的:探讨桂枝茯苓胶囊治疗慢性盆腔炎气滞血瘀证的临床疗效。方法:将80例慢性盆腔炎患者随机分为对照组与观察组各40例。对照组采用左氧氟沙星注射液及替硝唑静脉滴注,苦参栓直肠给药治疗;观察组在对照组基础加用桂枝茯苓胶囊治疗。连续治疗2个月经周期后,记录不同时点气滞血瘀证候评分,检测治疗前后血液流变学指标,并采用世界卫生组织生活质量测定简表(WHOQOL-BREF)评价患者生活质量。结果:总有效率治疗组为97.5%,对照组为82.5%,2组比较,差异有统计学意义(P<0.05)。治疗后2组血液流变学指标高切全血黏度、低切全血黏度、血浆黏度和血沉均较治疗前改善(P<0.01);观察组上述各指标改善优于对照组(P<0.01)。治疗后2组生存质量、健康状况、日常活动及自我感觉四个维度评分及总分均较治疗前明显升高(P<0.01);治疗后观察组上述指标评分均高于对照组(P<0.01)。治疗后4、8周2组气滞血瘀证候评分呈下降趋势(P<0.01),观察组治疗后第4、8周的证候评分均低于对照组(P<0.01)。结论:桂枝茯苓胶囊口服能改善慢性盆腔炎气滞血瘀证临床症状,提高临床疗效。
Objective: To investigate the curative effect of Guizhi Fuling Capsule in treating chronic pelvic inflammatory stasis syndrome. Methods: 80 patients with chronic pelvic inflammatory disease were randomly divided into control group and observation group, 40 cases each. The control group was treated with levofloxacin injection and tinidazole intravenously, and the kushenli suppository was administered rectally. The observation group was treated with Guizhi Fuling capsule on the basis of the control group. After 2 consecutive menstrual cycles, the blood stasis syndrome scores at different time points were recorded, and the hemorrheological indexes were measured before and after treatment. The quality of life of the patients was evaluated by WHOQOL-BREF. Results: The total effective rate was 97.5% in the treatment group and 82.5% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the indexes of hemorheology in high shear group were significantly higher than those in control group (P <0.01); the whole blood viscosity, low whole blood viscosity, plasma viscosity and erythrocyte sedimentation rate were improved ). After treatment, the scores of the four dimensions of quality of life, health status, daily activities and self-feeling of the two groups were significantly higher than those before treatment (P <0.01). After treatment, the scores of the above indexes in the observation group were higher than those in the control group (P < 0.01). After 4 and 8 weeks of treatment, the scores of qi stagnation syndrome and blood stasis syndrome showed a decreasing trend (P <0.01). The scores of syndromes of observation group were lower than those of the control group (P <0.01) at 4 and 8 weeks after treatment. Conclusion: Guizhi Fuling capsules can improve the clinical symptoms of chronic pelvic inflammatory stasis syndrome and improve the clinical curative effect.