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目的:本实验旨在揭示脑缺血-再灌注损伤前后大鼠血浆血栓素B2(TXB2)及6-酮前列腺环素F1(6-Keto-PGF1α)的动态变化。方法:制作脑缺血-再灌注大鼠模型,45只健康SD大鼠随机分为正常对照组、模型组和假手术组大鼠。在术后1天、3天、5天和7天分别观察大鼠血浆TXB2和6-Keto-PGF1α含量。结果:线栓大脑中动脉后造成脑缺血,血浆TXB2含量和TXB2/6-Keto-PGF1α比值明显高于假手术组和正常对照组(p<0.05或0.01),在缺血第1天最显著。结论:脑缺血-再灌注损伤后,血浆TXB2和TXB2/6-Keto-PGF1α的变化规律可为临床缺血性脑损伤治疗提供重要参考。
Objective: This experiment aims to reveal the dynamic changes of plasma TXB2 and 6-Keto-PGF1α in rats before and after cerebral ischemia-reperfusion injury. Methods: A rat model of cerebral ischemia - reperfusion was established. Forty healthy SD rats were randomly divided into normal control group, model group and sham operation group. The levels of TXB2 and 6-Keto-PGF1α in plasma of rats were observed on the 1st, 3rd, 5th and 7th day after operation. Results: The middle cerebral artery occlusion caused by cerebral ischemia, the content of TXB2 and the ratio of TXB2 / 6-Keto-PGF1α were significantly higher than those in sham group and normal control group (p <0.05 or 0.01) Significant. Conclusion: The changes of TXB2 and TXB2 / 6-Keto-PGF1α in plasma after cerebral ischemia-reperfusion injury may provide important reference for the treatment of clinical ischemic brain injury.