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选用Methotrex(?)tum(以下简为Met),通过动物试验,人为的使动物发病,就药物对机体骨髓抑制及胚胎发育的影响等方面作了较详细的观察和记载。 Met是一种无菌的黄粉末,规格每只为5mg(由上海第十二制药厂生产)。临用前,用无菌注射用水溶解并稀释不同浓度梯度。本试验所用的动物均为已性成熟的,健康的,但尚未有过性行为的小白鼠(由武汉生物制品所提供)。体重雄鼠为27～30g,雌鼠为25～28g,按雌雄为2:1的比例分笼饲养,每笼为一组,每组有12只,共设有6组,其中一组为
Methotrex(TM) tum (hereafter referred to as Met) was selected and animal experiments were conducted to artificially affect the animals. The effects of drugs on bone marrow suppression and embryo development were observed and recorded in detail. Met is a sterile yellow powder with a specification of 5 mg each (produced by Shanghai No. 12 Pharmaceutical Factory). Before use, dissolve and dilute different concentration gradients with sterile water for injection. The animals used in this experiment were all mature, healthy mice that had not had sex (as provided by Wuhan Biological Products). Male rats weighing 27 to 30g, females 25 to 28g, according to the ratio of male to female 2:1 divided cage feeding, each cage is a group of 12 in each group, a total of 6 groups, one of which is