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目的观察卡介苗 (BCG)膀胱内灌注预防膀胱癌复发的长期疗效。方法 75例膀胱移行细胞癌患者行膀胱部分切除术后分为两组 ,一组采用BCG 80mg加生理盐水 5 0ml膀胱内灌注 ,每周 1次 ,8次后改每月 1次 ,持续 2年。对照组为拒绝行BCG灌注或仅灌注 1～ 2次者。结果随访 74例 ,1例失访 ,随访时间 18个月～ 12年 ,平均 75个月。 75例中坚持灌注治疗 2年者 6 1例 ,术后 3、5、7年复发率分别为 6 .5 6 %、2 1.31%、31.15 % ;对照组 14例 ,随访 13例 ,3、5、7年复发率分别为 4 6 .15 %、6 1.5 4 %和 6 9.2 3%。维持灌注组首次复发时间平均为 5 2个月 ,而对照组平均复发时间为37个月。结论BCG膀胱内维持灌注可有效降低膀胱癌的近期及远期复发率。
Objective To observe the long-term curative effect of intravesical instillation of BCG to prevent recurrence of bladder cancer. Methods 75 patients with bladder transitional cell carcinoma underwent partial bladder resection and divided into two groups. One group received intravesical instillation of BCG 80mg plus normal saline 50ml, once a week, once a month for 8 times and then for 2 years . The control group refused to line BCG perfusion or perfusion only 1 or 2 times. Results A total of 74 cases were followed up and 1 case was lost. The follow-up time ranged from 18 months to 12 years with an average of 75 months. The 75 cases were treated with perfusion for 2 years, 61 cases, the recurrence rates at 3, 5 and 7 years were 6.66%, 2.31% and 31.15% respectively. The control group was followed up for 13 cases and 3,5 The recurrence rates at 7 years were 46.1%, 6 1.54% and 6 9.23%, respectively. The mean time to relapse in the maintenance perfusion group was 52 months, while the mean recurrence time in the control group was 37 months. Conclusion Intravesical BCG infusion can effectively reduce the short-term and long-term recurrence of bladder cancer.