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以 2′ 脱氧尿苷为原料 ,先用甲磺酰氯将 3′ ,5′ 羟基保护制得化合物 (2 ) ,然后在氢氧化钠水溶液中形成 3′ ,5′ O 环状物 (3) ,再与叔丁醇钾 (t BuOK)作用生成 (4) ,最后通过Pd C加氢得到目标化合物 2′ ,3′ 二脱氧尿苷 (5 ) ,总收率为 2 1 2 % .
Using 2’-deoxyuridine as starting material, the compound (2) is prepared by protecting the 3 ’, 5’ hydroxyl group with methanesulfonyl chloride and then forming the 3 ’, 5’ O cyclic compound (3) in aqueous sodium hydroxide solution (4) was formed by the action of tBuOK, finally the target compound 2 ’, 3’ dideoxyuridine (5) was hydrogenated by Pd C and the total yield was 21.2%.