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恶性肿瘤的患者往往对感染的抵抗力有下降现象,作者们试用死菌疫苗制剂(Paspat)治疗头颈部恶性肿瘤患者的易感染倾向,以嗜中性白细胞吞噬功能作为断定疗效的指标,对7名患者进行了观察。7例患者包括上颌癌3名,扁桃体恶性淋巴瘤2名,上颌脂肪肉瘤1名,喉癌1名,都曾施行全部或部分切除手术、放疗或化疗。所用的治疗方法为:皮内注射paspat 0.2 ml,每周一次,连续使用2～3个月,分别在使用前后检查嗜中性白细胞吞噬功能。检查方法:在从患者末梢血分离出的白细胞中,加入作为调理素的正常人血清,和葡萄球菌(死菌)一起在37℃下进行120分钟震动培养,离心后镜检,计算吞噬细菌的白细胞百分比。结果:嗜中性自细胞吞噬率治疗前平均值是24.3％,而治疗后上升至47.6％。
Patients with malignant tumors tend to have reduced resistance to infection. The authors used Paspat to treat susceptibility to infections in patients with head and neck malignancies, and used neutrophil phagocytosis as an indicator of efficacy. Seven patients were observed. Seven patients included 3 maxillary carcinomas, 2 malignant tonsil lymphomas, 1 maxillary liposarcoma, and 1 laryngeal carcinoma. They had undergone all or partial resections, radiotherapy, or chemotherapy. The treatment used was: intradermal injection of 0.2 ml of paspat, once a week, continuous use for 2 to 3 months, neutrophil phagocytosis before and after use, respectively. Examination method: In the leukocytes isolated from the patient’s peripheral blood, normal human serum as an opsonin is added, and staphylococcus (death bacteria) is incubated together at 37°C for 120 minutes, after centrifugation, microscopic examination is performed to calculate phagocytic bacteria. The percentage of white blood cells. Results: The mean value of the neutrophil phagocytosis rate before treatment was 24.3%, and rose to 47.6% after treatment.