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1 文献来源rnZagouri F,Sergentanis TN,Chrysikos D,et al.mTOR inhibitors in breast cancer:A systematic review[J].Gynecol Oncol,2012,127(3):662-672.rn2 证据水平rn1a.rn3 背景rnPI3K/AKT/mTOR通路是肿瘤进展过程的关键媒介.