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CXC趋化因子受体4(CXCR4)属于G蛋白耦联7次跨膜受体,是CXC趋化因子家族成员基质细胞衍生因子1(SDF-1)/CXCL12的惟一受体,广泛表达在许多细胞表面,与其配体SDF-1构成的SDF-1-CXCR4生物学轴,参与调节许多生物学活性作用,不仅调节胚胎发育、干细胞归巢和组织/器官的损伤修复,而且与很多疾病的发生和发展有关,成为一些疾病治疗的分子靶目标。本文对其研究进展予以综述。
CXC chemokine receptor 4 (CXCR4) belongs to the G protein-coupled 7th transmembrane receptor and is the only receptor for the CXC chemokine family member stromal cell-derived factor 1 (SDF-1) / CXCL12 and is widely expressed in many The cell surface, with the SDF-1-CXCR4 biological axis composed of its ligand SDF-1, is involved in the regulation of many biological activities not only regulating embryonic development, stem cell homing and tissue / organ damage repair, but also with many diseases Related to development and becoming a molecular target of some disease treatments. This article reviews its research progress.